Intro
Dr. Bulman is an Associate Professor in the Department of Pharmacy Practice at the University of Illinois Chicago and runs the Precision Antimicrobial Laboratory. His group aims to devise novel therapeutic approaches that are capable of successfully treating infectious diseases while also suppressing the amplification of new resistance mechanisms. His laboratory is developing cutting-edge pharmacokinetic and pharmacodynamic treatment approaches for antibiotics to help combat multidrug-resistant bacteria. Implementing clinical pharmacokinetic data from patients, Dr. Bulman’s lab simulates the human exposures of antimicrobials in the laboratory to evaluate their pharmacodynamic effects.
Ongoing work aims to repurpose and revitalize older antibiotics for bacteria with emerging resistance mechanisms in preparation for continued clinical outbreaks of carbapenem-resistant Gram-negatives. Dr. Bulman is currently leading a project that is exploring combinations between aminoglycosides and β-lactam/β-lactamase inhibitors for these highly resistant pathogens (2022-2027, R01AI173064). The Precision Antimicrobial Laboratory also seeks to develop models that can predict phenotypic resistance based on bacterial genotype. Dr. Bulman is also interested in optimizing treatment of biofilms and the use of inhaled antibiotics for patients with pneumonia.